SiliaBond Acids, Bases & Others 선택 가이드 

 

In order to simplify the use and the removal of acids / bases and their salts from reaction mixtures, 

SiliCycle has developed a range of silica bound SiliaBond acids and bases. 

 

 

Acids 

 

Best SiliaBond Acids	Typical Reactions & Applications Examples
SiliaBond Carboxylic Acid	Nucleophilic acyl substitutions: esters hydrolysis, Fisher esterifications, amides hydrolysis, etc. A chromatographic phase week cation exchanger at pH ≥ 6.8 that can be eluted at a pH ≤ 2.8
SiliaBond Propylsulfonic Acid	Nucleophilic acyl substitutions such as transesterifications, etc. Carbon-carbon coupling reactions
SiliaBond Tosic Acid	A chromatographic phase strong cation exchanger that is permenently negatively charged (pKa < 1) Ionic scavenging Deprotections of aromatic ethers Fries rearrangements

 

 

Bases 

 

Best SiliaBond Bases	Typical Reactions & Applications Examples
SiliaBond Amine	Organic scavenging of electrophiles Ionic scavenging Nucleophilic-catalyzed reactions Acid-catalyzed reactions: Aldol reactions, Retro-Claisen reaction, Mannich reactions...
SiliaBond Carbonate	Ionic scavenging Nitro-Aldol (Henry) reactions & Michael additions Amine free-basing Compatible with solvent-free conditions
SiliaBond Dimethylamine	Knoevenagel condensations Catch andd release purification of compounds bearing a permanent negative charge such as salts of sulfonic acids
SiliaBond Guanidine	Alkylations Strecker-type reactions Etherifications such as Williamson synthesis Michael additions and more generally speaking 1,4 addition reactions Ionic scavenging Deprotonates moderately acidic hydrogens
SiliaBond Morpholine	Acid sponge Enamine formations Mannich condensations Less nucleophilic and less basic than piperidine hence forming stable chloramines
SiliaBond Piperazine	Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups Knoevenagel condensations Ionic & nucleophile scavenger
SiliaBond Piperidine	Deprotecting and scavenging agent for Fmoc and Bsmoc amino protecting groups Knoevenagel condensations Ketones to enamines conversions Production of dipiperidinyl dithiuram tetrasulfide (rubber vulcanization accelerator)

 

 

Linkers 

Synthesis of homemade functionalized silicas according to your very own application

SiliaBond	Typical Reactions & Applications Examples
SiliaBond Allyl	Allylic oxidations Ene reactions Tsuji-Trost reactions Rancidification
SiliaBond Bromophenyl	Introduction of phenyl groups via Pd-catalyzed couplings Synthesis of Grignard reagents
SiliaBond Glycidoxy	Immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups Ring-opening reactions & hydrolysis Reduction with tungsten hexachloride Reduction with lithium aluminum hydride
SiliaBond Phenylmethylchloride	Nucleophilic substitutions for introduction of phenyl linker
SiliaBond Propyl Bromide	Nucleophilic substitutions for introduction of n-propyl linker